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Membrane permeability testing, systems and accessories

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Membrane permeability testing, systems and accessories

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Founded in 1973, PermeGear is recognized as a leader in the diffusion cell industry and continues to make hundreds of varieties of Franz cells, Side-Bi-Side cells, and In-Line cells. Custom diffusion cells are a specialty.

PermeGear automated systems incorporate In-Line cells, a peristaltic pump, a fraction collector, and a heater/circulator into a versatile system for analyzing flux over time.

All PermeGear automated diffusion ...

Related literature


Founded in 1973, PermeGear is recognized as a leader in the diffusion cell industry and continues to make hundreds of varieties of Franz cells, Side-Bi-Side cells, and In-Line cells. Custom diffusion cells are a specialty.

PermeGear automated systems incorporate In-Line cells, a peristaltic pump, a fraction collector, and a heater/circulator into a versatile system for analyzing flux over time.

All PermeGear automated diffusion cell systems are based on the continuous flow principle. A multi-channel peristaltic pump draws receptor solution from a reservoir through a distribution manifold and sends it to the In-Line cells. The cells are warmed to 32ºC by a heater/circulator that pumps water through the cell warmer in which the In-Line Cells are located. After filling the receptor chambers of the cells and purging the system of bubbles, the subject compound is then placed in the donor chambers of the cells. From that time, the fluid is collected in the vials of the fraction collector at user set time intervals. The vials are taken for analysis manually after the sampling time has elapsed.

PermeGear V-Series manual diffusion systems are employing Franz Cells for carrying out in vitro release testing (IVRT) and in vitro permeation testing (IVPT). The systems enable a researcher to measure the release or permeation of a compound into or through membranes.

\r\nPermeGear H-Series manual diffusion systems are made for use with Side-Bi-Side cells. All but the H1 stirrers have aluminum supply manifolds mounted toward the rear, which connect to a heater/circulator. The long horizontal manifold tubes have hose barb fittings that allow the water jackets of the diffusion cells to be connected to them with latex tubing. PermeGear’s Side-Bi-Side Cells are currently in laboratories around the world and used for everything from measuring the migration of molecules into and/or through biological membranes to an instrument of measurement in the development of fuel cells. To best mimic in vivo conditions, permeation experiments are typically done at near normal body temperature. Therefore, the fluid inside each chamber of a Side-Bi-Side Cell is heated and stirred.\r\n\r\n
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Membrane permeability testing, systems and accessories